The relationship between the hematologic indices (PDW, WBC count, MPV) at the admission time and descending ST segment after thrombolysis in patients with myocardial infarction
Keywords:
Hematologic indices, thrombolysis, myocardial infarction, ST segment
Abstract
WBC count and the platelet index (MPV) at the admission time of patients with STEMI, are the strong predictors for undesirable outcomes of patients. The objective of the present study was to determine the relationship between the hematologic indices including MPV and WBC count at the admission time of patients with ST resolution index in patients with STEMI who were treated by thrombolytic agents.
In this prospective study, venous blood samples of 114 patients with STEMI were taken to determine PDW, MPV and WBC count at patients' referral time and before thrombolytic therapy. According to ST resolution index in 90 minutes after thrombolytic therapy, patients were classified in two groups with ST resolution less than 50% and ST resolution of 50% or more. Finally, values of the laboratory indices above were compared between two ST-resolution groups that this issue was carried out using the SPSS version 21 software.
In assessing through ROC curve analysis, it was determined that measuring MPV is not considered as an accurate and effective index in predicting ST resolution after thrombolysis (Area Under Curve: 0.574). WBC count was not an applicable indicator for predicting ST resolution after thrombolysis, as well (Area Under Curve: 0.660). Finally, the results of multiple logistic regression model showed that the only predictor of ST resolution less than 50% is the history of using statins so that history of using statin increased the probability of ST resolution less than 50% for 7 times (P: 0.028, OR: 7.306).
There is not a relationship between the occurrence of complete ST resolution (more than 50%) and the values of both MPV and WBC indices. So, measuring these two indicators may not have the enough validity for predicting ST resolution after thrombolysis. According to our study, patients with history of using statins have a lower prevalence of complete ST resolution (more than 50%).
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References
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Antman, E. M., Giugliano, R. P., Gibson, C. M., McCabe, C. H., Coussement, P., Kleiman, N. S., ... & Van der Wieken, R. (1999). Abciximab facilitates the rate and extent of thrombolysis: results of the Thrombolysis in Myocardial Infarction (TIMI) 14 trial. Circulation, 99(21), 2720-2732.
Antman, E. M., Giugliano, R. P., Morrow, D. A., McCabe, C. H., Cutler, S. S., Charlesworth, A., ... & Braunwald, E. (2000). Comparison of a 60-versus 90-minute determination of ST-segment resolution after thrombolytic therapy for acute myocardial infarction. In TIME-II Investigators. Intravenous nPA for Treatment of Infarcting Myocardium Early-II. The American journal of cardiology, 86(11), 1235-7.
Carlsson, J., Kamp, U., Härtel, D., Brockmeier, J., Meierhenrich, R., Miketic, S., ... & Tebbe, U. (1999). Resolution of ST-segment elevation in acute myocardial infarction—Early prognostic significance after thrombolytic therapy. Herz, 24(6), 440-447..
Claeys, M. J., Bosmans, J., Veenstra, L., Jorens, P., De Raedt, H., & Vrints, C. J. (1999). Determinants and prognostic implications of persistent ST-segment elevation after primary angioplasty for acute myocardial infarction: importance of microvascular reperfusion injury on clinical outcome. Circulation, 99(15), 1972-1977.
Darabad, B. R., Vatandust, J., Khoshknab, M. P., & Poorrafsanjani, M. H. (2014). Survey of the effect of opioid abuse on the extent of coronary artery diseases. Global journal of health science, 6(7), 83.
de Lemos, J. A., Antman, E. M., Gibson, C. M., McCabe, C. H., Giugliano, R. P., Murphy, S. A., ... & Van Der Wieken, R. (2000). Abciximab improves both epicardial flow and myocardial reperfusion in ST-elevation myocardial infarction: observations from the TIMI 14 trial. Circulation, 101(3), 239-243.
de Lemos, J. A., Antman, E. M., Giugliano, R. P., Morrow, D. A., McCabe, C. H., Charlesworth, A., ... & Braunwald, E. (2000). Very early risk stratification after thrombolytic therapy with a bedside myoglobin assay and the 12-lead electrocardiogram. American heart journal, 140(3), 373-378.
Dissmann, R., Linderer, T., Goerke, M., von Ameln, H., Rennhak, U., & Schröder, R. (1993). Sudden increase of the ST segment elevation at time of reperfusion predicts extensive infarcts in patients with intravenous thrombolysis. American heart journal, 126(4), 832-839.
Heris, S. O., Rahimi, B., Faridaalaee, G., Hajahmadi, M., Sayyadi, H., & Naghipour, B. (2014). QT dispersion after thrombolytic therapy. International cardiovascular research journal, 8(4), 161.
Huczek, Z., Kochman, J., Filipiak, K. J., Horszczaruk, G. J., Grabowski, M., Piatkowski, R., ... & Opolski, G. (2005). Mean platelet volume on admission predicts impaired reperfusion and long-term mortality in acute myocardial infarction treated with primary percutaneous coronary intervention. Journal of the American College of Cardiology, 46(2), 284-290.
Ito, H., Maruyama, A., Iwakura, K., Takiuchi, S., Masuyama, T., Hori, M., ... & Minamino, T. (1996). Clinical implications of the ‘no reflow’phenomenon: a predictor of complications and left ventricular remodeling in reperfused anterior wall myocardial infarction. Circulation, 93(2), 223-228.
Ito, H., Tomooka, T., Sakai, N., Yu, H., Higashino, Y., Fujii, K., ... & Minamino, T. (1992). Lack of myocardial perfusion immediately after successful thrombolysis. A predictor of poor recovery of left ventricular function in anterior myocardial infarction. Circulation, 85(5), 1699-1705.
Khademvatan, K., Alinejad, V., Eghtedar, S., Rahbar, N., & Agakhani, N. (2014). Survey of the relationship between metabolic syndrome and myocardial infarction in hospitals of Urmia University of medical sciences. Global journal of health science, 6(7), 58.
Khademvatani, K., M. Basiri, V. Alinejad, and M. H. Seyed Mohammad Zad. "Prevalence and correlates of aortic root dilatation in patients with essential hypertension admitted to Seyedoshohada Hospital, Urmia 2012-2013." Journal of Global Pharma Technology 2, no. 8 (2016): 01-06.
Kim, J. S., Kim, J., Choi, D., Lee, C. J., Lee, S. H., Ko, Y. G., ... & Yang, J. Y. (2010). Efficacy of high-dose atorvastatin loading before primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: the STATIN STEMI trial. JACC: Cardiovascular Interventions, 3(3), 332-339.
Kırbaş, Ö., Kurmuş, Ö., Köseoğlu, C., Duran Karaduman, B., Saatçi Yaşar, A., Alemdar, R., ... & Bilge, M. (2014). Association between admission mean platelet volume and ST segment resolution after thrombolytic therapy for acute myocardial infarction. Anadolu Kardiyol Derg, 14(8), 728-732.
Kondo, M., Tamura, K., Tanio, H., & Shimono, Y. (1993). Is ST segment re-elevation associated with reperfusion an indicator of marked myocardial damage after thrombolysis?. Journal of the American College of Cardiology, 21(1), 62-67.
Massberg, S., Schulz, C., & Gawaz, M. (2003). Role of platelets in the pathophysiology of acute coronary syndrome. In Seminars in vascular medicine (Vol. 3, No. 02, pp. 147-162). Copyright© 2003 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.:+ 1 (212) 584-4662.
Matetzky, S., Freimark, D., Chouraqui, P., Novikov, I., Agranat, O., Rabinowitz, B., ... & Hod, H. (1998). The distinction between coronary and myocardial reperfusion after thrombolytic therapy by clinical markers of reperfusion. Journal of the American College of Cardiology, 32(5), 1326-1330.
Matetzky, S., Novikov, M., Gruberg, L., Freimark, D., Feinberg, M., Elian, D., ... & Rabinowitz, B. (1999). The significance of persistent ST elevation versus early resolution of ST segment elevation after primary PTCA. Journal of the American College of Cardiology, 34(7), 1932-1938.
Miida, T., Oda, H., Toeda, T., & Higuma, N. (1994). Additional ST-segment elevation immediately after reperfusion and its effect on myocardial salvage in anterior wall acute myocardial infarction. American Journal of Cardiology, 73(12), 851-855.
Morrow, D. A., Antman, E. M., Charlesworth, A., Cairns, R., Murphy, S. A., de Lemos, J. A., ... & Braunwald, E. (2000). TIMI risk score for ST-elevation myocardial infarction: a convenient, bedside, clinical score for risk assessment at presentation: an intravenous nPA for treatment of infarcting myocardium early II trial substudy. Circulation, 102(17), 2031-2037.
Neumann, F. J., Blasini, R., Schmitt, C., Alt, E., Dirschinger, J., Gawaz, M., ... & Schömig, A. (1998). Effect of glycoprotein IIb/IIIa receptor blockade on recovery of coronary flow and left ventricular function after the placement of coronary-artery stents in acute myocardial infarction. Circulation, 98(24), 2695-2701.
Ohman, E. M., Armstrong, P. W., Christenson, R. H., Granger, C. B., Katus, H. A., Hamm, C. W., ... & Califf, R. M. (1996). Cardiac troponin T levels for risk stratification in acute myocardial ischemia. New England Journal of Medicine, 335(18), 1333-1342.
Ohman, E. M., Armstrong, P. W., White, H. D., Granger, C. B., Wilcox, R. G., Weaver, W. D., ... & Topol, E. J. (1999). Risk stratification with a point-of-care cardiac troponin T test in acute myocardial infarction. The American journal of cardiology, 84(11), 1281-1286.
Ohman, E. M., Kleiman, N. S., Gacioch, G., Worley, S. J., Navetta, F. I., Talley, J. D., ... & Miller, M. (1997). Combined accelerated tissue-plasminogen activator and platelet glycoprotein IIb/IIIa integrin receptor blockade with Integrilin in acute myocardial infarction: results of a randomized, placebo-controlled, dose-ranging trial. Circulation, 95(4), 846-854.
Poorrafsanjani, M. H., & Darabad, B. R. (2014). Evaluate the sensitivity and specificity echocardiography in trans-Doppler and tissue Doppler method in the estimation of left ventricular end-diastolic pressure. Global journal of health science, 6(7), 92.
Purcell, I. F., Newall, N., & Farrer, M. (1997). Change in ST segment elevation 60 minutes after thrombolytic initiation predicts clinical outcome as accurately as later electrocardiographic changes. Heart, 78(5), 465-471.
Sabatine, M. S., Morrow, D. A., Cannon, C. P., Murphy, S. A., Demopoulos, L. A., DiBattiste, P. M., ... & Gibson, C. M. (2002). Relationship between baseline white blood cell count and degree of coronary artery disease and mortality in patients with acute coronary syndromes: a TACTICS-TIMI 18 substudy. Journal of the American College of Cardiology, 40(10), 1761-1768.
Saran, R. K., Been, M., Furniss, S. S., Hawkins, T., & Reid, D. S. (1990). Reduction in ST segment elevation after thrombolysis predicts either coronary reperfusion or preservation of left ventricular function. Heart, 64(2), 113-117.
Schröder, R., Dissmann, R., Brüggemann, T., Wegscheider, K., Linderer, T., Tebbe, U., & Neuhaus, K. L. (1994). Extent of early ST segment elevation resolution: a simple but strong predictor of outcome in patients with acute myocardial infarction. Journal of the American College of Cardiology, 24(2), 384-391.
Schröder, R., Wegscheider, K., Schröder, K., Dissmann, R., Meyer-Sabellek, W., & INJECT Trial Group. (1995). Extent of early ST segment elevation resolution: a strong predictor of outcome in patients with acute myocardial infarction and a sensitive measure to compare thrombolytic regimens: a substudy of the International Joint Efficacy Comparison of Thrombolytics (INJECT) trial. Journal of the American College of Cardiology, 26(7), 1657-1664.
Schröder, R., Zeymer, U., Wegscheider, K., & Neuhaus, K. L. (1999). Comparison of the predictive value of ST segment elevation resolution at 90 and 180min after start of streptokinase in acute myocardial infarction. A substudy of the Hirudin for Improvement of Thrombolysis (HIT)-4 Study. European heart journal, 20(21), 1563-1571.
Shah, A., Wagner, G. S., Granger, C. B., O’Connor, C. M., Green, C. L., Trollinger, K. M., ... & Krucoff, M. W. (2000). Prognostic implications of TIMI flow grade in the infarct related artery compared with continuous 12-lead ST-segment resolution analysis: reexamining the “gold standard” for myocardial reperfusion assessment. Journal of the American College of Cardiology, 35(3), 666-672.
Somitsu, Y., Nakamura, M., Degawa, T., & Yamaguchi, T. (1997). Prognostic value of slow resolution of ST-segment elevation following successful direct percutaneous transluminal coronary angioplasty for recovery of left ventricular function. The American journal of cardiology, 80(4), 406-410.
Stubbs, P., Collinson, P., Moseley, D., Greenwood, T., & Noble, M. (1996). Prognostic significance of admission troponin T concentrations in patients with myocardial infarction. Circulation, 94(6), 1291-1297.
Trial of abciximab with and without low-dose reteplase for acute myocardial infarction. (2000). Strategies for Patency Enhancement in the Emergency Department (SPEED) Group. Circulation, 101, 2788-2794.
Vagdatli, E., Gounari, E., Lazaridou, E., Katsibourlia, E., Tsikopoulou, F., & Labrianou, I. (2010). Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia, 14(1), 28.
van der Loo, B., & Martin, J. F. (1999). A role for changes in platelet production in the cause of acute coronary syndromes. Arteriosclerosis, thrombosis, and vascular biology, 19(3), 672-679.
van't Hof, A. W., Liem, A., de Boer, M. J., Zijlstra, F., & Zwolle Myocardial Infarction Study Group. (1997). Clinical value of 12-lead electrocardiogram after successful reperfusion therapy for acute myocardial infarction. The Lancet, 350(9078), 615-619.
Varasteh-Ravan, H. R., Ali-Hassan-Sayegh, S., Shokraneh, S., Mozayan, M. R., & Karimi-bondarabadi, A. A. (2013). Relationship of admission mean platelet volume, platelet distribution width and white blood cells with ST resolution in patients with acute ST segment elevation myocardial infarction treated with streptokinase without history of previous cardiovascular surgery. Perspectives in clinical research, 4(2), 125.
Woo, J. S., Cho, J. M., Kim, S. J., Kim, M. K., & Kim, C. J. (2011). Combined assessments of biochemical markers and ST-segment resolution provide additional prognostic information for patients with ST-segment elevation myocardial infarction. Korean circulation journal, 41(7), 372-378.
Yalcin, A. A., Topuz, M., Akturk, I. F., Celik, O., Erturk, M., Uzun, F., ... & Oner, E. (2015). Is There a Correlation Between Coronary Artery Ectasia and Neutrophil–Lymphocyte Ratio?. Clinical and Applied Thrombosis/Hemostasis, 21(3), 229-234.
Antman, E. M., Giugliano, R. P., Gibson, C. M., McCabe, C. H., Coussement, P., Kleiman, N. S., ... & Van der Wieken, R. (1999). Abciximab facilitates the rate and extent of thrombolysis: results of the Thrombolysis in Myocardial Infarction (TIMI) 14 trial. Circulation, 99(21), 2720-2732.
Antman, E. M., Giugliano, R. P., Morrow, D. A., McCabe, C. H., Cutler, S. S., Charlesworth, A., ... & Braunwald, E. (2000). Comparison of a 60-versus 90-minute determination of ST-segment resolution after thrombolytic therapy for acute myocardial infarction. In TIME-II Investigators. Intravenous nPA for Treatment of Infarcting Myocardium Early-II. The American journal of cardiology, 86(11), 1235-7.
Carlsson, J., Kamp, U., Härtel, D., Brockmeier, J., Meierhenrich, R., Miketic, S., ... & Tebbe, U. (1999). Resolution of ST-segment elevation in acute myocardial infarction—Early prognostic significance after thrombolytic therapy. Herz, 24(6), 440-447..
Claeys, M. J., Bosmans, J., Veenstra, L., Jorens, P., De Raedt, H., & Vrints, C. J. (1999). Determinants and prognostic implications of persistent ST-segment elevation after primary angioplasty for acute myocardial infarction: importance of microvascular reperfusion injury on clinical outcome. Circulation, 99(15), 1972-1977.
Darabad, B. R., Vatandust, J., Khoshknab, M. P., & Poorrafsanjani, M. H. (2014). Survey of the effect of opioid abuse on the extent of coronary artery diseases. Global journal of health science, 6(7), 83.
de Lemos, J. A., Antman, E. M., Gibson, C. M., McCabe, C. H., Giugliano, R. P., Murphy, S. A., ... & Van Der Wieken, R. (2000). Abciximab improves both epicardial flow and myocardial reperfusion in ST-elevation myocardial infarction: observations from the TIMI 14 trial. Circulation, 101(3), 239-243.
de Lemos, J. A., Antman, E. M., Giugliano, R. P., Morrow, D. A., McCabe, C. H., Charlesworth, A., ... & Braunwald, E. (2000). Very early risk stratification after thrombolytic therapy with a bedside myoglobin assay and the 12-lead electrocardiogram. American heart journal, 140(3), 373-378.
Dissmann, R., Linderer, T., Goerke, M., von Ameln, H., Rennhak, U., & Schröder, R. (1993). Sudden increase of the ST segment elevation at time of reperfusion predicts extensive infarcts in patients with intravenous thrombolysis. American heart journal, 126(4), 832-839.
Heris, S. O., Rahimi, B., Faridaalaee, G., Hajahmadi, M., Sayyadi, H., & Naghipour, B. (2014). QT dispersion after thrombolytic therapy. International cardiovascular research journal, 8(4), 161.
Huczek, Z., Kochman, J., Filipiak, K. J., Horszczaruk, G. J., Grabowski, M., Piatkowski, R., ... & Opolski, G. (2005). Mean platelet volume on admission predicts impaired reperfusion and long-term mortality in acute myocardial infarction treated with primary percutaneous coronary intervention. Journal of the American College of Cardiology, 46(2), 284-290.
Ito, H., Maruyama, A., Iwakura, K., Takiuchi, S., Masuyama, T., Hori, M., ... & Minamino, T. (1996). Clinical implications of the ‘no reflow’phenomenon: a predictor of complications and left ventricular remodeling in reperfused anterior wall myocardial infarction. Circulation, 93(2), 223-228.
Ito, H., Tomooka, T., Sakai, N., Yu, H., Higashino, Y., Fujii, K., ... & Minamino, T. (1992). Lack of myocardial perfusion immediately after successful thrombolysis. A predictor of poor recovery of left ventricular function in anterior myocardial infarction. Circulation, 85(5), 1699-1705.
Khademvatan, K., Alinejad, V., Eghtedar, S., Rahbar, N., & Agakhani, N. (2014). Survey of the relationship between metabolic syndrome and myocardial infarction in hospitals of Urmia University of medical sciences. Global journal of health science, 6(7), 58.
Khademvatani, K., M. Basiri, V. Alinejad, and M. H. Seyed Mohammad Zad. "Prevalence and correlates of aortic root dilatation in patients with essential hypertension admitted to Seyedoshohada Hospital, Urmia 2012-2013." Journal of Global Pharma Technology 2, no. 8 (2016): 01-06.
Kim, J. S., Kim, J., Choi, D., Lee, C. J., Lee, S. H., Ko, Y. G., ... & Yang, J. Y. (2010). Efficacy of high-dose atorvastatin loading before primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: the STATIN STEMI trial. JACC: Cardiovascular Interventions, 3(3), 332-339.
Kırbaş, Ö., Kurmuş, Ö., Köseoğlu, C., Duran Karaduman, B., Saatçi Yaşar, A., Alemdar, R., ... & Bilge, M. (2014). Association between admission mean platelet volume and ST segment resolution after thrombolytic therapy for acute myocardial infarction. Anadolu Kardiyol Derg, 14(8), 728-732.
Kondo, M., Tamura, K., Tanio, H., & Shimono, Y. (1993). Is ST segment re-elevation associated with reperfusion an indicator of marked myocardial damage after thrombolysis?. Journal of the American College of Cardiology, 21(1), 62-67.
Massberg, S., Schulz, C., & Gawaz, M. (2003). Role of platelets in the pathophysiology of acute coronary syndrome. In Seminars in vascular medicine (Vol. 3, No. 02, pp. 147-162). Copyright© 2003 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.:+ 1 (212) 584-4662.
Matetzky, S., Freimark, D., Chouraqui, P., Novikov, I., Agranat, O., Rabinowitz, B., ... & Hod, H. (1998). The distinction between coronary and myocardial reperfusion after thrombolytic therapy by clinical markers of reperfusion. Journal of the American College of Cardiology, 32(5), 1326-1330.
Matetzky, S., Novikov, M., Gruberg, L., Freimark, D., Feinberg, M., Elian, D., ... & Rabinowitz, B. (1999). The significance of persistent ST elevation versus early resolution of ST segment elevation after primary PTCA. Journal of the American College of Cardiology, 34(7), 1932-1938.
Miida, T., Oda, H., Toeda, T., & Higuma, N. (1994). Additional ST-segment elevation immediately after reperfusion and its effect on myocardial salvage in anterior wall acute myocardial infarction. American Journal of Cardiology, 73(12), 851-855.
Morrow, D. A., Antman, E. M., Charlesworth, A., Cairns, R., Murphy, S. A., de Lemos, J. A., ... & Braunwald, E. (2000). TIMI risk score for ST-elevation myocardial infarction: a convenient, bedside, clinical score for risk assessment at presentation: an intravenous nPA for treatment of infarcting myocardium early II trial substudy. Circulation, 102(17), 2031-2037.
Neumann, F. J., Blasini, R., Schmitt, C., Alt, E., Dirschinger, J., Gawaz, M., ... & Schömig, A. (1998). Effect of glycoprotein IIb/IIIa receptor blockade on recovery of coronary flow and left ventricular function after the placement of coronary-artery stents in acute myocardial infarction. Circulation, 98(24), 2695-2701.
Ohman, E. M., Armstrong, P. W., Christenson, R. H., Granger, C. B., Katus, H. A., Hamm, C. W., ... & Califf, R. M. (1996). Cardiac troponin T levels for risk stratification in acute myocardial ischemia. New England Journal of Medicine, 335(18), 1333-1342.
Ohman, E. M., Armstrong, P. W., White, H. D., Granger, C. B., Wilcox, R. G., Weaver, W. D., ... & Topol, E. J. (1999). Risk stratification with a point-of-care cardiac troponin T test in acute myocardial infarction. The American journal of cardiology, 84(11), 1281-1286.
Ohman, E. M., Kleiman, N. S., Gacioch, G., Worley, S. J., Navetta, F. I., Talley, J. D., ... & Miller, M. (1997). Combined accelerated tissue-plasminogen activator and platelet glycoprotein IIb/IIIa integrin receptor blockade with Integrilin in acute myocardial infarction: results of a randomized, placebo-controlled, dose-ranging trial. Circulation, 95(4), 846-854.
Poorrafsanjani, M. H., & Darabad, B. R. (2014). Evaluate the sensitivity and specificity echocardiography in trans-Doppler and tissue Doppler method in the estimation of left ventricular end-diastolic pressure. Global journal of health science, 6(7), 92.
Purcell, I. F., Newall, N., & Farrer, M. (1997). Change in ST segment elevation 60 minutes after thrombolytic initiation predicts clinical outcome as accurately as later electrocardiographic changes. Heart, 78(5), 465-471.
Sabatine, M. S., Morrow, D. A., Cannon, C. P., Murphy, S. A., Demopoulos, L. A., DiBattiste, P. M., ... & Gibson, C. M. (2002). Relationship between baseline white blood cell count and degree of coronary artery disease and mortality in patients with acute coronary syndromes: a TACTICS-TIMI 18 substudy. Journal of the American College of Cardiology, 40(10), 1761-1768.
Saran, R. K., Been, M., Furniss, S. S., Hawkins, T., & Reid, D. S. (1990). Reduction in ST segment elevation after thrombolysis predicts either coronary reperfusion or preservation of left ventricular function. Heart, 64(2), 113-117.
Schröder, R., Dissmann, R., Brüggemann, T., Wegscheider, K., Linderer, T., Tebbe, U., & Neuhaus, K. L. (1994). Extent of early ST segment elevation resolution: a simple but strong predictor of outcome in patients with acute myocardial infarction. Journal of the American College of Cardiology, 24(2), 384-391.
Schröder, R., Wegscheider, K., Schröder, K., Dissmann, R., Meyer-Sabellek, W., & INJECT Trial Group. (1995). Extent of early ST segment elevation resolution: a strong predictor of outcome in patients with acute myocardial infarction and a sensitive measure to compare thrombolytic regimens: a substudy of the International Joint Efficacy Comparison of Thrombolytics (INJECT) trial. Journal of the American College of Cardiology, 26(7), 1657-1664.
Schröder, R., Zeymer, U., Wegscheider, K., & Neuhaus, K. L. (1999). Comparison of the predictive value of ST segment elevation resolution at 90 and 180min after start of streptokinase in acute myocardial infarction. A substudy of the Hirudin for Improvement of Thrombolysis (HIT)-4 Study. European heart journal, 20(21), 1563-1571.
Shah, A., Wagner, G. S., Granger, C. B., O’Connor, C. M., Green, C. L., Trollinger, K. M., ... & Krucoff, M. W. (2000). Prognostic implications of TIMI flow grade in the infarct related artery compared with continuous 12-lead ST-segment resolution analysis: reexamining the “gold standard” for myocardial reperfusion assessment. Journal of the American College of Cardiology, 35(3), 666-672.
Somitsu, Y., Nakamura, M., Degawa, T., & Yamaguchi, T. (1997). Prognostic value of slow resolution of ST-segment elevation following successful direct percutaneous transluminal coronary angioplasty for recovery of left ventricular function. The American journal of cardiology, 80(4), 406-410.
Stubbs, P., Collinson, P., Moseley, D., Greenwood, T., & Noble, M. (1996). Prognostic significance of admission troponin T concentrations in patients with myocardial infarction. Circulation, 94(6), 1291-1297.
Trial of abciximab with and without low-dose reteplase for acute myocardial infarction. (2000). Strategies for Patency Enhancement in the Emergency Department (SPEED) Group. Circulation, 101, 2788-2794.
Vagdatli, E., Gounari, E., Lazaridou, E., Katsibourlia, E., Tsikopoulou, F., & Labrianou, I. (2010). Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia, 14(1), 28.
van der Loo, B., & Martin, J. F. (1999). A role for changes in platelet production in the cause of acute coronary syndromes. Arteriosclerosis, thrombosis, and vascular biology, 19(3), 672-679.
van't Hof, A. W., Liem, A., de Boer, M. J., Zijlstra, F., & Zwolle Myocardial Infarction Study Group. (1997). Clinical value of 12-lead electrocardiogram after successful reperfusion therapy for acute myocardial infarction. The Lancet, 350(9078), 615-619.
Varasteh-Ravan, H. R., Ali-Hassan-Sayegh, S., Shokraneh, S., Mozayan, M. R., & Karimi-bondarabadi, A. A. (2013). Relationship of admission mean platelet volume, platelet distribution width and white blood cells with ST resolution in patients with acute ST segment elevation myocardial infarction treated with streptokinase without history of previous cardiovascular surgery. Perspectives in clinical research, 4(2), 125.
Woo, J. S., Cho, J. M., Kim, S. J., Kim, M. K., & Kim, C. J. (2011). Combined assessments of biochemical markers and ST-segment resolution provide additional prognostic information for patients with ST-segment elevation myocardial infarction. Korean circulation journal, 41(7), 372-378.
Yalcin, A. A., Topuz, M., Akturk, I. F., Celik, O., Erturk, M., Uzun, F., ... & Oner, E. (2015). Is There a Correlation Between Coronary Artery Ectasia and Neutrophil–Lymphocyte Ratio?. Clinical and Applied Thrombosis/Hemostasis, 21(3), 229-234.
Published
2019-02-27
How to Cite
Raberi, V., Ezati, E., & Zadeh, R. (2019). The relationship between the hematologic indices (PDW, WBC count, MPV) at the admission time and descending ST segment after thrombolysis in patients with myocardial infarction. Amazonia Investiga, 8(18), 139-149. Retrieved from https://www.amazoniainvestiga.info/index.php/amazonia/article/view/290
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